Hemoglobin and its Function in 3D

Vanda Janštová, Petr Novotný


volume: 29
year: 2020
issue: 1
fulltext: PDF
elektronická příloha

online publishing date: 30/3/2020
DOI: 10.14712/25337556.2020.1.3
ISSN (Online): 2533-7556

Licence Creative Commons
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Proteins are one of the basic groups of macromolecules which are part of all cells (and viruses) and play crucial roles in them. Visualization of protein structure and its changes in 2D can be a challenge. Another challenge for students is in connecting knowledge about different levels such as DNA – protein structure – phenotype. Therefore, it is advisable to seek out options on how to visualize structures and actions which are too small to be observed directly. In this paper, we present an interactive three-dimensional online encyclopedia of (mainly) protein, nucleic acid and other macromolecular structures, Proteopedia ( Proteopedia contains a great deal of information, e.g., visualization of protein structures which can be used while teaching biology or science. As with Wikipedia, registered users can create content. A description of creating mutations from existing Proteopedia sites in other languages is a part of the presented paper. A tutorial “How do we get the oxygen we breathe” was translated as a first example from the Czech version of the Proteopedia site. This tutorial shows the relationship between protein structure and its function, as well as the influence of a single nucleotide DNA mutation on both protein structure and function causing sickle cell anemia.


structure, protein, model, plasticity, sickle cell anemia, hemoglobin, Proteopedia

fulltext (PDF )



Duncan, R. G. (2007). The Role of Domain-Specific Knowledge in Generative Reasoning About Complicated Multileveled Phenomena. Cognition and Instruction, 25(4), 271–336.

Duncan, R. G., Freidenreich, H. B., Chinn, C. A., & Bausch, A. (2011). Promoting Middle School Students’ Understandings of Molecular Genetics. Research in Science Education, 41(2), 147–167.

Duncan, R. G., & Reiser, B. J. (2007). Reasoning across ontologically distinct levels: Students’ understandings of molecular genetics. Journal of Research in Science Teaching, 44(7), 938–959.

Duncan, R. G., Rogat, A. D., & Yarden, A. (2009). A learning progression for deepening students’ understandings of modern genetics across the 5th–10th grades. Journal of Research in Science Teaching, 46(6), 655–674.

Duschl, R. A., Schweingruber, H. A., & Shouse, A. W. (2007). Taking science to school: Learning and teaching science in grades K-8.

Gelbart, H., & Yarden, A. (2006). Learning genetics through an authentic research simulation in bioinformatics. Journal of Biological Education, 40(3), 107–112.

Harlen, W., Bell, D., Devés, R., Dyasi, H., Fernández de la Garza, G., Léna, P., … Yu, W. (2015). Working with Big Ideas of Science Education. Získáno z

Hodis, E., Prilusky, J., Martz, E., Silman, I., Moult, J., & Sussman, J. L. (2008). Proteopedia- a scientific „wiki" bridging the rift between three-dimensional structure and function of biomacromolecules. Genome Biology, 9(8), R121.

Hodis, E., Prilusky, J., & Sussman, J. L. (2010). Proteopedia: A collaborative, virtual 3D web-resource for protein and biomolecule structure and function. Biochemistry and Molecular Biology Education, 38(5), 341–342.

Jančaříková, K. (2017). Modely v didaktice biologie. Biologie-Chemie-Zeměpis, 26(1).

Janštová, V., & Jáč, M. (2014). Modelování ve výuce biologie (1) aneb jak žákům přiblížit některé biologické jevy. Biologie Chemie Zeměpis, 23(2), 61–65.

Kurth, L. A., & Roseman, J. (2001). Findings from the high school biology curriculum study: Molecular basis of heredity. Annual Meeting of the National Association for Research in Science Teaching, St. Louis, MO.

Lewis, J., & Kattmann, U. (2004). Traits, genes, particles and information: re‐visiting students’ understandings of genetics. International Journal of Science Education, 26(2), 195–206.

Malacinski, G. M., & Zell, P. W. (1996). Manipulating the „Invisible“: Learning Molecular Biology Using Inexpensive Models. American Biology Teacher, 58(7), 428–432.

Marbach-Ad, G., & Stavy, R. (2000). Students’ cellular and molecular explanations of genetic phenomena. Journal of Biological Education, 34(4), 200–205.

Prilusky, J., & Hodis, E. (2012). Proteopedia entry: “Tutorial: How we get the oxygen we breathe”. Biochemistry and Molecular Biology Education, 40(5), 339–339. and Molecular Biology Education, 40(5), 339–339.

Venville, G. (2004). Young children learning about living things: A case study of conceptual change from ontological and social perspectives. Journal of Research in Science Teaching, 41(5), 449–480.

Venville, G., & Donovan, J. (2005). Searching for clarity to teach the complexity of the gene concept. Teaching Science: The Journal of the Australian Science Teachers Association, 51(3), 20–24.

Venville, G., Gribble, S. J., & Donovan, J. (2005). An exploration of young children’s understandings of genetics concepts from ontological and epistemological perspectives. Science Education, 89(4), 614–633.

Wu, H.-K., Krajcik, J. S., & Soloway, E. (2001). Promoting understanding of chemical representations: Students’ use of a visualization tool in the classroom. Journal of Research in Science Teaching, 38(7), 821–842.

Wikipedie: Studenti píší Wikipedii, on-line [23. 4. 2019].

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